Wednesday, July 24, 2019
Netflix Case Analysis Study Example | Topics and Well Written Essays - 1000 words
Netflix Analysis - Case Study Example On the basis of this an overview of analysis tools has been discussed such as the 3Cââ¬â¢s, STP and the 4 Pââ¬â¢s. The 3 Cââ¬â¢s model is used to provide an overview of the company. Based on this overview the market conditions can be assessed which help the managers in forming strategies for the company. Based on this the company can rectify its weaknesses and progress towards success. Company: Netflix is a DVD rental and online streaming business. The services offered by the company are in a combined form and these have attracted the customers. The services of the company are slow but once the videos are acquired then the services and facilities which are offered are unmatchable and incomparable. Customers: For the success of the business, the needs and requirements of the customer are important and therefore they should be assessed. The company has faced losses when a new strategy of separating both the practices was introduced. This also increased the subscription charges of the company. Competitors: The business faces competition from products like Apple iTunes, Amazon video on demand (VOD), Google TV and YouTube and others. All these provide similar services and have benefited highly from the splitting decision of the company (Dau, and Wesley). Segmentation: In this process the company will identify the segment which will be interested most with availing the services of the company. The company has segments its consumers in order to market them in a better way. by segmenting consumers, the company can do well in the market. Targeting: Finding the most appropriate segment and finding the factors which will satisfy these individuals most must be assessed. On the basis of this all the price and the product related strategies are formed. By targeting different segments in a different way, the company can get better results. Positioning: In this segment the appropriate industry is
Tuesday, July 23, 2019
The property market at world level ( credit crunch affected ) and How Essay
The property market at world level ( credit crunch affected ) and How this goes for Hong Kong market - Essay Example Thus the impact of this is far reaching and can provide insight into the future of Hong Kongââ¬â¢s property market as well as its overall financial infrastructure and how they can be affected. The reason for choosing this topic is therefore to study as to how this credit crunch will affect the world markets in general as well as Hong Kong Market in particular. Current credit crunch is largely perceived as the main reason behind the collapse of the property market in international system. The reason as to why credit crunch resulted into the collapse of the property market can be traced back to the subprime mortgage crises which emerged due to the imprudent lending practices of the bank. By definition, a subprime borrower is a borrower whose credit has not been entirely satisfactory due to historical defaults on payments against loans taken. (Budworth,2009). However, such borrowers offer more lucrative options for the banks and financial institutions to lend because of their higher risk. High risk borrowers are often charged high rates therefore there is always a chance to earn high on such relationships. Based on this simple principle of risk and return banks and financial institutions started to lend to their subprime borrowers especially in mortgage markets. However, banks and other financial institutions, at the same time, also started the process of securitization through which the mortgage portfolio held as security with the bank were bundled and securities were sold out against such collaterals in the open market. The basic purpose was to recoup the liquidity lost in making the loans to subprime borrowers. Crises in property markets started to emerge when subprime borrowers started to default on their commitments and as such banks have to pay out to the holders of mortgage backed securities through other means as with the default of the borrowers a mismatch in cash flows were created. The
Monday, July 22, 2019
Rhetorical Analysis compare Essay Example for Free
Rhetorical Analysis compare Essay This is a rhetorical essay comparing, Looking At Women, written by Scott Russell Sanders; and What Is A Homosexual?, Written by Andrew Sullivan. These two essays describe in detail how children are growing up and knowing at an early age that they are either heterosexual or homosexual. When comparing these two essays both boys are going through puberty, watching their body change and develop. Mr. Sanders essay is about boys learning when they are attracted to girls, usually its around the time they are going through puberty; while Mr. Sullivan essay is about when boys learn that they are attracted to boys. This also was when the boy went through puberty. Looking At Women is about when a boy realizes his body and mind are changing towards girls, and realizes his attraction toward girls. When you can look at a girl, and realize it is the opposite sex. Mr. Sanders talks about how should the male figure look at the female when they display their body with little to no clothing. He goes on to explain that its natural for us to look at the opposite sex. We as humans are curious in the opposite sex, so our eyes naturally wander and look. Upon reading these essays I realized we all go through puberty and that is basically when we find ourselves. Our wants and desires for either the same or the opposite sex. Having said that, what if you were not attracted to the opposite sex, but were attracted to the same sex. What Is A Homosexual is a persuasive essay about gay adolescents realizing they are attracted to the same sex at an early age. Mr. Sullivan realizes his attraction to the same sex after he went through puberty as the boy in Mr. Sanders essay noticing his attractions to girls. Both boys have to control their desires to look at either the opposite sex or the same sex. I realized that both boys are going through similar situations under different circumstances. While theà homosexual cant not be caught looking at another male while dressing in the locker room. But, the heterosexual can look at the opposite sex and want be picked on. In todays society the clothes for girls has changed sense I was a preteen and going through puberty. The preteens now wear little clothing as possible to show off their developing figure into a woman. This will attract the eyes of the young male thats also going through puberty, and doesnt want to be caught staring at the developing young female. This is also similar to the young boy that is having homosexual thoughts in the locker room. He has to control his action of staring at his same sex friend that has change over the summer from puberty. Both the boys are going through similar situations, one is with the same sex while the other is the opposite sex, finding sexual attraction and the urge to look and their desires for the other person. While Looking At Women and What Is A Homosexual seem very different, they are quite similar. The boys are going through the same body changes and realizing the attraction to either girls or guys. The boys are sorting out their desires on how to look at the other person weather its the opposite sex or the same. Interesting enough the boys learn to control their wandering eyes, and when its appropriate to look at either gender.
Sunday, July 21, 2019
Management of Patient With Vestibular Neuronitis (VN)
Management of Patient With Vestibular Neuronitis (VN) Stephen Chiang (21209166) Rural GP Case 2GP CLINIC Presenting complaint TW is a 22 year old woman who was presented with a 3 day history of dizziness and light-headedness. History of presenting complaint Patient first experienced dizziness and light-headedness after returning from her holiday in Sydney. History of viral URTI 4 weeks ago which has been resolved. Describes the dizziness as ââ¬Å"walking on airâ⬠and feeling unstable on her feet. Patient denies any sensation of vertigo ââ¬â ââ¬Å"head spinningâ⬠or ââ¬Å"everything spinningâ⬠. Associated with a right- sided headache that worsens the day after. Also associated with nausea, malaise and myalgia. Denies any vomiting. Symptoms are exacerbated by changing position ââ¬â getting out from bed and standing up from sitting position. Relieved by resting in a dark, quiet room. Patient denies any visual symptoms (flashes), tinnitus or deafness. No recent head injury or ingestion of any drugs ââ¬â alcohol marijuana Pt went to see a physiotherapist ?vertigo but no abnormalities was detected by the physiotherapist. No nystagmus. Patient admits dizziness improved slightly with the hall-pike manoeuvre. Past Medical History Nil Medications Estelle-35 ED tablets2mg/35mcgdaily No known drug allergies Family History Nil remarkable Social History TW works as a hair stylist. Lives with her parents and siblings. Non-smoker and occasional ETOH consumption 2-3 standard drinks a week. Diet consists of take outs and fast food. Moderate physical activities. Examinations Pleasant looking young woman. Not in any obvious pain or distress. Vitals ââ¬â BP 118/80, HR 80, RR 18, afebrile, no signs of anaemia. ENT ââ¬â NAD on otoscope examination, no redness, swelling or discharge. Weber and Rinne test grossly intact. Optic ââ¬â visual acuity 6/6 on L and R eye. No evidence of nystagmus on examination. Cardiovascular ââ¬â Dual heart sound noted, nil added. No postural drop of blood pressure. Cranial nerves ââ¬â olfactory sensation intact. Visual field and pupillary light reflex normal. Nil ptosis, diplopia and good accommodation. Light touch on the cheeks and forehead grossly intact. Power of muscle of mastication 5/5. Facial nerve intact and NAD. No deviations and fasciculation of tongue and uvula. Accessory muscles 5/5. Cerebellum ââ¬â Normal gait, good coordination, negative dysdiadochokinesia and negative rhomberg test. Normal reflexes and no past pointing. Negative Hallpike manoeuvre. Investigations Ordered Nil Murtaghââ¬â¢s Diagnostic Model Management Plan 1. Viral vestibular neuronitis Reassurance and careful explanation to patient about nature of disease. Symptomatic treatment of nausea, prochlorperazine prescribed. Supportive treatment at home, bed rest and special vestibular exercises ââ¬â explained by GP. Avoid movement or position that exacerbates symptoms. Return to GP if no resolution of symptoms. Follow up Patient did not represent to GP practice during my placement. Preventative Health Activities 1. Nutrition ââ¬â education and advice on healthy diet plan 2. Alcohol ââ¬â education on appropriate alcohol intake, early recognition or drinking problem 3. Sexual health ââ¬â education for prevention of sexually transmitted infection and contraception. 4. Physical activity ââ¬â encourage importance of physical activities. Clinical Evidence Base In the management of patient with vestibular neuronitis (VN), is the usage of pharmacological treatment (glucocorticoid) more effective in terms of recovery compared to supportive treatment alone. Vestibular neuronitis is defined as the dysfunction of the peripheral vestibular system with associated vertigo, nausea and vomiting.5 Hearing symptoms such as deafness and tinnitus are rarely associated with vestibular neuronitis.3 Up to today, the cause of vestibular neuronitis remains unknown hence, the main treatment options remain unclear limiting it to corticosteroids, antiviral therapy and vestibular exercises.1,4 The OneSearch UWA library database was searched and keywords used were ââ¬Å"acuteâ⬠, ââ¬Å"vestibular neuronitisâ⬠, ââ¬Å"corticosteroidâ⬠, ââ¬Å"conservative treatmentâ⬠and ââ¬Å"head manoeuvreâ⬠. Other related terms were also included in the search. One study was identified, ââ¬Å"Corticosteroid and vestibular exercises in vestibular neuronitisâ⬠by John K. Goudakos, MSc; Konstantinos D. Markou, George Psillas, Victor Vital, Miltiadis Tsaligopoulos.1 The study is single-blind randomised clinical trial measuring the recovery of 40 patients with vestibular neuronitis by using vestibular exercises vs corticosteroid at 1, 6 and 12 months.1 The 40 patients were randomised into 2 groups where one received corticosteroid therapy and the other underwent vestibular exercises for 3 weeks.1 Recovery was measured by monitoring the scores on the European Evaluation of Vertigo scale (EEV), Dizziness Handicap Inventory (DHI) and vestibular evoked myogenic potentials (VEMPs).1 Patient included in the study were: Aged 18-80 presenting with history of acute onset associated with vertigo, nausea, vomiting, postural imbalance, no hearing loss, no central lesion on neurological examination, horizontal nystagmus with rotational component, ipsilateral deficit on the head thrust test and unilateral reduced calorie response on the electronystagmography(ENG).1 Patient excluded from the study were: glaucoma, recent infection, signs of central vestibular dysfunction, history of chronic vestibular dysfunction, hearing loss and patients that are contraindicated for steroid use.1 Results: At 1 month, the EEV in both group showed an improvement with a score of 3.75 in the vestibular exercise group and 4.17 in the corticosteroid group. However (P>0.05) hence there is not significant difference between the two groups.1 At the 6 months follow up, 35% of the patient in the corticosteroid group had a complete disease resolution compared to 5% in the vestibular exercise group, (P1 At the 12 months follow up for disease resolution, 50% of patient in the corticosteroid group showed complete disease resolution and 45% of the patient in the vestibular exercise group showed disease resolution however (P>0.05) hence there was no significant difference.1 Strength and Weaknesses This study is level II based on the NHMRC. Methods of measuring outcome were clearly explained. Inclusion and exclusion criteria were well defined. Single-blinded study. No statistically significant difference in age, sex and disease onset between both groups. Small sample size of 40 patients. Method of randomisation was not defined, may include bias. Measurement of recovery did not include other factors. Tools of measurement such as VEMPs are good for diagnostic clarification but not measurement of disease. Measurement did not include clinical improvement. Application ââ¬â This study showed that there is a quicker resolution of vestibular neuronitis in the short term within 6 months of corticosteroid therapy. However in the long term follow up, (12 months) the efficacy of corticosteroid therapy is similar to vestibular exercises. Further studies should be performed combining vestibular exercises with corticosteroid therapy with a larger sample size to measure efficacy. In this case, my GP did not offer corticosteroid therapy to the patient but educated the patient on vestibular exercises which corresponds to the finding above because corticosteroid therapy does not offer additional long term benefits. References 1. John K. Goudakos, MD, MSc; Konstantinos D. Markou, MD, PhD; George Psillas, MD, PhD; Victor Vital, MD, PhD; Miltiadis Tsaligopoulos, MD, PhD. Corticosteroids and Vestibular Exercises in Vestibular Neuritis Single-blind Randomized Clinical Trial.JAMA Otolaryngol Head Neck SurgeryPublished online March 6, 2014.; 140(5) pages 434-440 2. Mikael L.-Ãâ¦. Karlberg and Mà ¥ns Magnusson. Treatment of Acute Vestibular Neuronitis With Glucocorticoids.Otology Neurotology2011; 32 pages 1140-1143 3. Keith A Marill, MD.Vestibular Neuronitis. http://emedicine.medscape.com/article/794489-overview#a5 (accessed 18 June 2015) 4. John Murtagh AM.Murtaghs General Practise, Fifth edition ed. Published in Australia: McGraw-Hill Australia Pty Ltd; This fifth edition published 2011 5. John C. Goddard MD and Jose N. Fayad MD. Vestibular Neuritis.Otolaryngologic Clinics of North America2011; 44(2)pages 361-365
Analysis of Solubility and Forming Microemulsions
Analysis of Solubility and Forming Microemulsions Chapter 5 Materials and methods to studyà formulation models 5.1. Materials Oils and Surfactants: Ethyl Oleate obtained from Sigma-Aldrich; FK-Sunflower Oil obtained from Fresenius Kabi; FK-MCT Oil obtained from Fresenius Kabi; Miglyol 840 obtained from Sasol; Tween 80 viscous liquid obtained from Sigma-Aldrich; Labrasol obtained from Gattefossà ©; Model API. Devices: Sartorius, Scale Extend, Model ED2245; IKA RET basic, magnetic stirrer; Thermo Electron Corporation, HERAEUS Pico17 centrifuge; UV-spectrophotometer, Eppendorf BioSpectrometer, Kinetic. Other Equipment: Magnetic stir bars; Disposable plastic eppis, Eppendorf, with volume 1.5ml; Disposable plastic cuvettes, Plastibrand, 1.5ml semimicro (12.5 x 12.5 x 45mm); Disposable plastic pipettes, Eppendorf 3ml; Metal spatulas; Glass beakers; Glass bottles with lids; Disposable latex gloves; Protective glasses, shoes and lab coat. Specialized software: Origin Pro 8, by OriginLab Corporation. 5.2. Solubility tests To evaluate which oils and surfactants present better results at forming microemulsions, we pre-selected four different oils and two different surfactants to perform solubility tests with our model API. The oils tested were Ethyl Oleate, FK-Sunflower Oil, FK-MCT Oil, and Miglyol 840. Moreover, the surfactants used were Tween 80 viscous liquid and Labrasol. As shown in Fig. 1 solubility tests were performed using the following method: Firstly, an excessive amount of our API was added with a metal spatula to a concentrate (oil, surfactant or mixture). The chemicals were precisely weighed, and the resulting suspension was mixed, at room temperature, for 16h at 480rpm, at 21à ºC, on the magnetic stirrer. Secondly, the resulting mixed suspension was transferred to disposable plastic eppis and centrifuged at 10000 g for 10min. Thirdly, a new dilution was prepared using the supernatant that resulted from centrifugation. This new dilution must be much less concentrated in order to be measured by UV-Spectrometry. Lastly, the dilution was taken for analytics in a UV-spectrophotometer, where the absorbance values were measured at 425nm, using disposable plastic cuvettes. Other materials used during the procedure were disposable plastic pipettes, small glass beakers and small glass bottles with lids. The method was repeated three times for each oil, surfactant and mixture stock solution. The dilutions were also repeated three times for higher accuracy in the results. Fig. 1. Scheme showing the solubility test procedure. In order to analyze the data, the maximum values of diluted API in the concentrate were calculated from a calibration line for each of the mixtures (API + concentrate) being tested. The UV-spectrometry measurements were repeated three times for more accurate results. 4.3. Emulsifying capacity evaluation by PDMPD method In the second phase of our formulations study, we wanted to evaluate emulsifying capacity. We used the Phase Diagram by Micro Plate Dilution (PDMPD) method that consists in gradually diluting the oil phase with the water phase in a microtitre plate. The PDMPD method is an efficient and innovative approach that allows time and material savings while creating pseudo ternary phase diagrams for microemulsions and nanoemulsions. Compared with the traditional titration method (drop method), the PDMPD method enables a more exact status description of mixtures in pseudo ternary diagrams. It offers as well the possibility of examining the dilution stages simultaneously on just one microplate (Schmidts et al., 2009). Microemulsion assays consisting of a water phase, an oil phase, and a surfactant phase were prepared on microtiter plates (96 wells) as shown in Fig. 1 and described by Maeder, U., et. al in ââ¬Å"Hardware and software system for automatic microemulsion assay evaluation by analysis of optical propertiesâ⬠(2010) with slight modifications. Fig.1. Filling scheme for the microtiter plates. Inside each well, the upper value corresponds to the water phase and the bottom value to the oil plus surfactant phase. The preparation is described bellow: Firstly, the mixtures of oil and surfactants were prepared by weighing (Sartorius, Scale Extend, model ED2245), adding, and magnetically stirring the chosen oil and surfactant. The magnetic stirring process is done using the IKA RET basic, magnetic stirrer, at speed 480rpm, for one hour, at 21à ºC. To evaluate the five different ratios between one oil and one surfactant five different mixtures were prepared, as shown in Table 1. In total 20 mixtures were tested to assess the following mixtures: Tween80+EO; Tween80+MCT; Tween80+Mig840 and Tween80+(MCT,EO). For more accurate results, each was prepared and tested three times making a total of sixty mixtures made. Oil 1 Phase % Surfactant 1 Phase % Mixture 1 50 50 Mixture 2 40 60 Mixture 3 30 70 Mixture 4 20 80 Mixture 5 10 90 Table 1. Oil1/Surfactant1 mixing ratios Secondly, the wells were filled in two steps: In the first phase, starting in A1 and finishing in D4 the mixture is gradually loaded in the wells using a Pipette Research Plus, 200à µl, and disposable plastic pipette tips, Eppendorf, 200à µl. The filling process must be done with care to avoid air bubbles, which is especially hard with the more viscous oils. If air bubbles are present, the plate is not valid for the study and must be thrown away. In the second step, the aqueous phase is added, starting at D5 with 200à ¼l up to A2 with 5à ¼l. The microtitre plates used were Thermo Scientific* Nunc Flat Bottom 96-well polystyrene transparent plates with lids, 350à µl/well. The wells E1 to H5 of the same plate were loaded following the same procedure, but with a different mixture (different ratio of the surfactant and oil phase). Following this scheme, two fixed surfactant/oil-ratios can be placed on every plate. Table 2, below, illustrates the distribution. Plates Wells Content 1 A1-D5 Mixture 1 + Water 1 E1-H5 Mixture 2 + Water 2 A1-D5 Mixture 3 + Water 2 E1-H5 Mixture 4 + Water 3 A1-D5 Mixture 5 + Water Table 2. Mixtures distribution by plates Finally, the plates were sealed with their respective lids and were set in a Biometra, Rocking Platform, model WT15, for 16h, at maximum speed, with controlled temperature of 21à ºC. At the end of the 16h, the plates were scanned using a RICOH Aficio, scanner, model MP-C2551 with a pre-prepared marked lid. Each plate was repeated a minimum of three times and in different days. From the analysis of the several repetitions, it was determined which combinations resulted in the formation of microemulsion. This study consisted of observing the scans and attributing a 0 when a well showed turbidity and a 1 when was transparent, and it was possible to see clearly the marked dot on the bottom of the well. Two observers did this analysis and the results were crossed checked. When the sum of the three test was 2 or 3, the preparation was considered an emulsion. When the sum was 0 or 1, it was not considered an emulsion as depicted in Table 3. Table 3. Determination of emulsifying capacity of wells A1-A7 of plates 16, 21 and 25 containing a mixture of Tween80% and Mig840 (1:1). After the determination of emulsifying capacity phase diagrams were built. The software used was Origin Pro 8, by OriginLab Corporation. Fig. 2 shows one of the phase diagrams built. Each red point represents an emulsion formulation identified and each white point a non-emulsion. For each line in the diagram 3 plates were prepared and analyzed. Fig. 2 Phase diagram To develop this method, several pre-tests were made in different conditions. In the first experimental setup the vortex was used to shake 2 overlying plates, as shown on Fig.3, at speeds 3, 2 and 1 and then one single plate at speeds 3, 2 and 1, for 16h. These pre-tests showed unrepeatable results and spilling. Therefore, the method was changed: the vortex was substituted by the rocking platform. Different time periods were also pre-tested. Testing plates were set on the rocking platform for 8h, 9h, 16h, 18h, 20h and 22h. The chosen mixing time was 16h as it was the minimum length time tested for which reproducible results were observed, i.e., 18h, 20h and 22h showed the same results as 16h mixing on the Rocket Platform. Fig. 3 ââ¬â abandoned experimental setup using vortex and two overlying plates
Saturday, July 20, 2019
Gene Therapy Essay -- Genetic Engineering
Gene Therapy Parents can now pick a kidââ¬â¢s sex and screen for genetic illness. Will they someday select brains and beauty too? In the ever- advancing technological world, scientists discover new and efficient ways to advance society each and every single day. Imagine being able to choose your childââ¬â¢s body type, or personality, or IQ. It is not as farfetched as it sounds. Itââ¬â¢s a process called ââ¬Å"Gene Therapyâ⬠, and is being perfected right now. This process rules out any unknownââ¬â¢s in childbirth. It will not only allow us to determine the childââ¬â¢s sex, but also his future. In natural child conception, the mother provides the the two X chromosomes and the father provides the X and Y chromosomes. The balance of genetic make up is determined by the father since he is the only one that has the diversity of genes. With all this, the genetic combinations are completely random, allowing much room for fault. With science controlling the joining of such chromosomes, many of the fatal or physically impairing infant diseases will disappear. Scientistââ¬â¢ say they can pick out disease causing genes in the pre-natal stage before they grow. Controlling infant disease is only one aspect of the new technology. Determining a childââ¬â¢s sex is also under discussion. As a very controversial topic, determining a childââ¬â¢s sex will also reflect on societyââ¬â¢s views of gender rolls in the world today. Many societies value men over women immensely, so will this reflect on the diversity...
Friday, July 19, 2019
Emily Dickinson :: essays research papers
Emily Dickinson The year 1830 is a crucial date in English history. You see, this is the year that one of the most influential poets in the world was born. Emily Dickinson was born in Amherst, Massachusetts, an old fashioned Puritan town. Rarely did she go outside to meet strangers or walk in the garden. Emily felt uncomfortable outside of her house and even if she did travel, it wasn't for more than one hour. She was greatly impacted by her father, who was a lawyer, politician, and treasurer of Amherst College. The turning point in Emily's life occurred while she was on a business trip in Washington D.C. with her father. There, Emily met a Presbyterian Minister. Soon enough, she deeply fell in love with this man , whose name was Charlies Wadsworth. Even though the two were acquaintances, Emily felt a bond between herself and the much older and already married minister. However, although Charles was kind to her, he did not return her love. Eight years later, in1862, Charlies left for San Francisco, Calafornia with his family. It was about this time that Emily totally secluded herself from the world and started what would be world famous poems throughout the future . She adopted her ideas on poetry from her personal life, her fondness of nature, death, and her dislike of organized religion. War is occasionally pulled into Emily's poems also. Emily seemed truly concerned over happenings in her personal life. So she mainly focused her writings on the loss of her lover. In "I Never Saw A Moor," she describes things that she had never seen or experienced before but she knows what they are about. Here, Emily is trying to express herself on why she thinks Charles left her. She is desperately searching for answers. Emily attempted to teach others a lesson when she wrote "Tell All The Turth, But Tell It Slant." In this work, she wishes that Charles had given her a reason why he left so abruptly. She is stressing that people should tell all the truth, but lay it down easily so it does not cause strife. "Heart! We Will Forget Him!" Explains her feelings that she still has for Charles. However, she strived to put memories of Charles behind her and to move on in life. Emily hoped to see her lost love in eternity sometime. On the other hand, her love for Charles was not the only thing that she wrote about. "The Spider Holds A Silver Ball" explains why we should admire a spider's web. A spider took an excessive amount of time to build the silver
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